Chimp attack victim who received face transplant sees rejection five years later

Charla Nash, who was mauled in 2009, returns to hospital where doctors hope ending experiment to wean her off anti-rejection drugs will reverse process

A Connecticut woman who underwent a face transplant five years ago after being attacked by a chimpanzee is back in a Boston hospital after doctors discovered her body is rejecting the transplant.

Charla Nash had been taking part in an experiment in which doctors at Boston’s Brigham and Women’s Hospital tried to wean her off the anti-rejection drugs she had been taking since the 2011 operation.

Nash’s publicist, Shelly Sindland, said doctors hope to reverse the rejection by ending the experiment.

Anti-rejection drugs can have serious side effects. The US military funded the experiment in the hopes the alternative treatment could help those needing transplants after returning from war.

“I gave it my all and know my participation in the study will still be beneficial,” Nash said in a statement to the Associated Press. “I’d do it all over again, if I could. The men and women serving our country are the true heroes.”

Nash recently discovered several unusual patches on her face, Sindland said. On Monday doctors did a biopsy and determined her body was rejecting the transplant, she said.

Sindland said Nash told her doctors were hopeful they could reverse the rejection by ending the experiment and putting her back on her original medication. If that attempt was unsuccessful it was not immediately clear what the next step would be, Sindland said.

Nash’s doctors and the hospital, where Nash is expected to remain at least through the weekend, did not immediately return calls and emails.

Immunosuppression drugs that transplant patients are typically given for the rest of their lives carry such risks as cancer, viral infections and kidney damage.

Because of those dangers, many transplants of non-vital body parts, such as thumbs, are not considered worth doing. But doctors say that could change if the drugs do not have to be a lifelong commitment.

The Pentagon, which also paid for Nash’s transplant, has provided grants to 14 medical facilities across the US through its hand and face transplantation program. In war, the face and the extremities are the most frequently injured parts of the body.

“I’m just happy I had the chance to help,” Nash said. “I wish I could have done more. I believe in the power of prayer and appreciate everyone who is praying for me.”

Nash lost her nose, lips, eyelids and hands in 2009, when she was mauled by her employer’s 200lb pet chimpanzee in Stamford, Connecticut. Doctors also had to remove her eyes because of a disease transmitted by the chimp.

She received new facial features taken from a dead woman and also underwent a double hand transplant. The hand transplant failed when her body rejected the tissue.

When Nash began the experiment involving the suspension of anti-rejection drugs, in March 2015, doctors said it would eventually include other patients. Its findings could potentially affect hundreds of thousands of people, military and civilian alike.

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